ADHD can be very debilitating for people. The prefrontal cortex is very underactive, which leads to difficulties focusing, following instructions, remaining patient, poor decision making, and staying organized. The limbic system, which contains the hippocampus and amygdala, is also impaired, which affects memory, troubling regulating emotions, and motivation. With a dysfunctional basal ganglia, one can have trouble sitting still, and the conscious awareness of the reticular activating system is not working properly as well.